Folic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Folic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD8, GBP2, and E2F2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid metabolic process activity versus CHD8 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CHD8 →	+0.514	+0.197	.001	<.001	3	6
BLOOD_Lymphoma	GBP2 →	-4.717	-0.227	<.001	.001	3	5
BLOOD_Lymphoma	E2F2 →	+2.448	+0.274	.002	.001	3	5
BLOOD_Lymphoma	SUPT16H →	+0.697	+0.298	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RNF20 →	+0.610	+0.189	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	UBXN2B →	+0.755	+0.294	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046655 vs CHD8 — BLOOD_Lymphoma

Explore this scatter interactively →