Tetrahydrofolate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC63, TLE4_S292, and UMPS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate biosynthetic process activity versus SEC63 in OV (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEC63 →	-0.250	-0.053	.004	<.001	3	6
GBM	TLE4_S292 →	+0.322	+0.043	.001	.009	3	4
LSCC	UMPS →	+0.307	+0.040	<.001	.004	3	4
CCRCC	BAZ2A →	-0.188	-0.042	.003	.001	3	3
LSCC	TOMM70 →	+0.380	+0.051	<.001	.004	3	3
CCRCC	ZC3H13_S1230 →	-0.663	-0.070	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046654 vs SEC63 — OV

Explore this scatter interactively →