Tetrahydrofolate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFD1L, SUPT16H, and ADAT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate biosynthetic process activity versus MTHFD1L in KIDNEY (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MTHFD1L →	+1.203	+0.178	.003	.001	3	7
BLOOD_Lymphoma	SUPT16H →	+0.775	+0.185	.001	<.001	3	6
KIDNEY	ADAT2 →	+1.194	+0.213	<.001	.001	2	7
LARGE_INTESTINE	RAD54B →	+0.664	+0.197	.002	.001	2	7
KIDNEY	SATB2 →	+1.462	+0.211	.003	.002	3	6
LIVER	SASS6 →	+0.883	+0.177	.006	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046654 vs MTHFD1L — KIDNEY

Explore this scatter interactively →