Tetrahydrofolate metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and CDC20_T70, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate metabolic process activity versus SMC2 in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.616	+0.055	<.001	<.001	3	6
LSCC	SMC4 →	+0.564	+0.072	<.001	<.001	3	6
LUAD	CDC20_T70 →	+0.846	+0.045	.002	.001	3	6
LSCC	CDK1 →	+0.706	+0.054	<.001	<.001	3	6
LSCC	MCM4 →	+0.697	+0.070	<.001	<.001	3	6
LSCC	MSH2 →	+0.572	+0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046653 vs SMC2 — LSCC

Explore this scatter interactively →