Positive regulation of alpha-beta T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell proliferation activity versus RCSD1 in GBM (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.711	+0.122	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.628	+0.122	<.001	<.001	3	10
GBM	SASH3 →	+0.619	+0.127	<.001	<.001	3	10
LSCC	SEPTIN1 →	+1.046	+0.161	<.001	<.001	3	10
LSCC	SIPA1_S839 →	+0.575	+0.096	<.001	<.001	3	10
OV	SPN_S355 →	+1.172	+0.050	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046641 vs RCSD1 — GBM

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