Positive regulation of alpha-beta T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCST, FAM78A, and APOL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell proliferation activity versus HCST in LSCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HCST →	+0.920	+0.447	<.001	<.001	3	9
HNSC	FAM78A →	+0.630	+0.418	<.001	<.001	3	9
HNSC	APOL3 →	+1.332	+0.545	<.001	<.001	3	9
BRCA	PTPN22 →	+0.791	+0.724	<.001	<.001	3	9
LUAD	CD96 →	+0.948	+0.296	<.001	<.001	3	9
HNSC	PYHIN1 →	+1.124	+0.480	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046641 vs HCST — LSCC

Explore this scatter interactively →