Positive regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TVP23B, PDXK, and MYH9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TVP23B grouped by Positive regulation of alpha-beta T cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TVP23B →	-0.597	-1.090	.001	<.001	3	4
BLOOD_Lymphoma	PDXK →	-1.322	-1.534	.004	.005	3	4
SOFT_TISSUE	MYH9 →	-1.671	-1.372	.005	.005	3	4
OVARY	EIF3D →	-0.541	-0.840	.002	.001	3	4
SOFT_TISSUE	GRN →	-0.990	-1.328	.002	<.001	3	4
STOMACH	QSOX1 →	-1.532	-1.152	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TVP23B by Positive regulation of alpha-beta T cell proliferation activity — BREAST

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