Negative regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL6, OSMR, and GLB1L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell differentiation activity versus BCL6 in UCEC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCL6 →	+0.680	+0.352	.002	.009	3	5
GBM	OSMR →	+0.601	+0.247	.002	.004	3	5
GBM	GLB1L3 →	-0.760	-0.340	<.001	<.001	3	4
COAD	IFITM3 →	+0.610	+0.291	.009	.001	3	4
GBM	C1RL →	+0.772	+0.311	<.001	<.001	3	4
GBM	IFITM2 →	+0.685	+0.370	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046639 vs BCL6 — UCEC

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