Regulation of alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WSCD1, CDK6, and GOLGA6L10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WSCD1 grouped by Regulation of alpha-beta T cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WSCD1 →	+1.002	+0.793	.006	.005	3	3
LUNG_SCLC	CDK6 →	+3.088	+0.885	<.001	.005	3	3
PANCREAS	GOLGA6L10 →	-0.548	-0.745	.004	.005	3	3
KIDNEY	TIMM44 →	+0.484	+1.084	.004	.005	3	3
KIDNEY	ILKAP →	+0.417	+1.064	.003	.009	3	3
LIVER	ARHGEF1 →	-1.196	-1.201	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WSCD1 by Regulation of alpha-beta T cell differentiation activity — OVARY

Explore this box plot interactively →