Positive regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of organ growth pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIMS3, STAT4, and ARHGAP26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIMS3 grouped by Positive regulation of organ growth-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RIMS3 →	-0.391	-1.732	<.001	<.001	3	4
CNS	STAT4 →	-0.258	-1.307	<.001	<.001	3	4
CNS	ARHGAP26 →	-0.144	-0.990	.004	<.001	3	4
OVARY	DSC2 →	+0.220	+1.485	.002	<.001	3	4
LIVER	KCNB1 →	-0.256	-1.507	.008	.002	3	4
CNS	IL36RN →	-0.241	-1.213	.003	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIMS3 by Positive regulation of organ growth activity — OVARY

Explore this box plot interactively →