Negative regulation of organ growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of organ growth pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED22, SLC35A1, and C1orf21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED22 grouped by Negative regulation of organ growth-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MED22 →	-0.673	-1.307	.005	.001	3	3
LUNG_SCLC	SLC35A1 →	+0.554	+1.036	.009	.007	3	3
STOMACH	C1orf21 →	+1.698	+0.207	.005	.007	3	3
STOMACH	SPINK5 →	+1.605	+0.224	.002	.007	3	3
BREAST	AIP →	-0.795	-0.689	<.001	.001	3	3
KIDNEY	SACS →	-0.694	-0.894	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED22 by Negative regulation of organ growth activity — LUNG_SCLC

Explore this box plot interactively →