Xenobiotic export from cell

Across TCGA patient cohorts, RNA activity of the Xenobiotic export from cell pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACSS1, BICD2, and CHDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic export from cell activity versus ACSS1 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ACSS1 →	+0.357	+0.038	<.001	.002	3	6
PDAC	BICD2 →	-0.213	-0.054	.002	.002	3	6
BRCA	CHDH →	+0.435	+0.032	.001	.006	3	6
UCEC	COLGALT1 →	-0.350	-0.063	.002	<.001	3	6
UCEC	CRYL1 →	+0.485	+0.070	<.001	<.001	3	6
BRCA	DDAH1 →	+0.625	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046618 vs ACSS1 — PDAC

Explore this scatter interactively →