Xenobiotic export from cell

Across TCGA cell cohorts, RNA activity of the Xenobiotic export from cell pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA1, PPP1R12A, and CUTC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA1 grouped by Xenobiotic export from cell-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ITGA1 →	-0.191	-0.110	.005	.003	3	5
LIVER	PPP1R12A →	-0.380	-0.223	.006	<.001	3	5
LUNG_NSCLC_LUSC	CUTC →	+0.275	+0.137	.001	.009	3	5
LIVER	CCDC47 →	+0.175	+0.197	.001	<.001	3	4
PANCREAS	SLC22A11 →	+0.360	+0.140	.004	.009	3	4
PANCREAS	HEXA →	+0.251	+0.091	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA1 by Xenobiotic export from cell activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →