Regulation of mitotic centrosome separation

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic centrosome separation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF3-AS1, CENPA, and STARD13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic centrosome separation activity versus KLF3-AS1 in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KLF3-AS1 →	-0.567	-0.631	.002	<.001	3	4
OV	CENPA →	+1.132	+0.913	<.001	<.001	3	3
OV	STARD13 →	-0.636	-0.644	.008	.001	3	3
GBM	UXT →	+0.319	+0.182	<.001	<.001	3	3
BRCA	UBR3 →	-0.594	-0.162	.002	.009	3	3
BRCA	CHD9 →	-0.400	-0.157	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046602 vs KLF3-AS1 — OV

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