Positive regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of centriole replication pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCAPG_S674, SMC4, and CDK1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of centriole replication activity versus NCAPG_S674 in LUAD (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCAPG_S674 →	+1.383	+0.136	<.001	<.001	3	10
LUAD	SMC4 →	+0.736	+0.143	<.001	<.001	3	10
LUAD	CDK1 →	+1.019	+0.136	<.001	<.001	3	10
BRCA	LIG1 →	+0.562	+0.059	<.001	<.001	3	10
LUAD	MCM3 →	+0.979	+0.147	<.001	<.001	3	10
LUAD	MCM6 →	+0.991	+0.146	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046601 vs NCAPG_S674 — LUAD

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