Positive regulation of centriole replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU1-91P, CERCAM, and RNU6-908P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of centriole replication activity versus RNU1-91P in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-91P →	+0.479	+0.448	<.001	.003	3	3
HNSC	CERCAM →	-0.608	-0.500	<.001	.004	3	2
HNSC	RNU6-908P →	+0.922	+0.512	.009	.004	3	2
HNSC	AKR1B1P6 →	+0.211	+0.505	.003	.002	3	2
OV	PPIAP26 →	-0.126	-0.693	.004	.002	3	2
BRCA	FBXO36 →	+0.673	+0.456	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046601 vs RNU1-91P — BRCA

Explore this scatter interactively →