Regulation of centriole replication

Across TCGA cell cohorts, RNA activity of the Regulation of centriole replication pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EML2, GOSR1, and EXOC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centriole replication activity versus EML2 in OVARY (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EML2 →	-1.142	-0.219	.003	.002	3	4
PANCREAS	GOSR1 →	-0.943	-0.177	<.001	.001	3	4
LARGE_INTESTINE	EXOC6 →	-0.751	-0.251	.007	.002	3	4
BLOOD_Lymphoma	TTLL12 →	-0.652	-0.154	.003	.003	3	4
BONE	RPUSD4 →	-0.872	-0.355	.001	.002	2	5
BLOOD_Lymphoma	MCRIP2 →	-0.783	-0.201	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046599 vs EML2 — OVARY

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