Negative regulation of viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral entry into host cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBA7, TRIM22, and CCDC102A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral entry into host cell activity versus UBA7 in GBM (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBA7 →	+0.417	+0.077	<.001	<.001	3	7
GBM	TRIM22 →	+0.422	+0.068	<.001	<.001	3	7
UCEC	CCDC102A →	+0.277	+0.072	.006	.001	3	6
GBM	HLA-DRB5 →	+1.370	+0.117	<.001	<.001	3	6
GBM	THEMIS2_T593 →	+0.600	+0.071	<.001	<.001	3	6
GBM	VIM →	+0.467	+0.081	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046597 vs UBA7 — GBM

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