Regulation of Ras protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Ras protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL10A, and GRPEL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Ras protein signal transduction activity versus RPL5 in LUAD (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL5 →	-0.230	-0.035	<.001	<.001	3	8
CCRCC	RPL10A →	-0.203	-0.033	<.001	<.001	3	8
LUAD	GRPEL1 →	-0.486	-0.040	<.001	<.001	3	8
BRCA	OLFML1 →	+0.803	+0.037	<.001	<.001	3	8
OV	RPL12 →	-0.241	-0.040	<.001	<.001	3	7
GBM	SEPTIN4 →	+0.697	+0.039	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046578 vs RPL5 — LUAD

Explore this scatter interactively →