Regulation of Ras protein signal transduction

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of Ras protein signal transduction pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and THCA, show the opposite pattern, with lower activity in tumor tissue.

HNSC, KIRC, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Female	III,IV	+0.039	<.001	12	view →
KIRC	All	All	+0.017	<.001	10	view →
KICH	Male	II,III,IV	−0.043	<.001	9	view →
THCA	All	All	−0.028	<.001	8	view →
LUSC	Female	All	−0.038	<.001	6	view →
LIHC	Female	All	+0.027	<.001	6	view →
CHOL	All	All	+0.068	<.001	5	view →
STAD	Male	II,III,IV	+0.041	.006	4	view →
BRCA	All	III,IV	−0.015	.026	4	view →
KIRP	Male	All	−0.013	.049	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0046578–HNSC

Open the HNSC breakdown →