Regulation of Ras protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Ras protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK6, ITCH, and NAGPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Ras protein signal transduction activity versus MAPK6 in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAPK6 →	+0.998	+0.662	<.001	.002	3	4
BLOOD_Leukemia	ITCH →	+0.936	+0.652	.001	.006	3	3
BLOOD_Leukemia	NAGPA →	-0.959	-0.799	<.001	.004	3	3
BLOOD_Leukemia	TIGD4 →	+0.509	+0.733	.002	.001	3	3
PANCREAS	RHPN2 →	-1.324	-0.237	.009	<.001	2	4
BONE	CD2AP →	+1.584	+1.939	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046578 vs MAPK6 — BLOOD_Leukemia

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