Development of primary female sexual characteristics

Across TCGA patient cohorts, RNA activity of the Development of primary female sexual characteristics pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf18, MEIS3, and PMP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary female sexual characteristics activity versus C3orf18 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C3orf18 →	+0.957	+0.381	<.001	<.001	3	4
BRCA	MEIS3 →	+1.169	+0.339	<.001	.001	3	3
BRCA	PMP22 →	+0.781	+0.306	<.001	.003	3	3
BRCA	EDA2R →	+0.710	+0.360	.001	.002	3	3
BRCA	RILPL2 →	+0.447	+0.370	<.001	<.001	3	3
BRCA	FAM182B →	+0.251	+0.311	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046545 vs C3orf18 — BRCA

Explore this scatter interactively →