Development of primary female sexual characteristics

Across TCGA pan-cancer cohorts, RNA activity of the Development of primary female sexual characteristics pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 105 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Development of primary female sexual characteristics pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, BRCA, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	IV	0.284	0.837	<.001	73	view →
BRCA	OS	Tertile	All	0.960	0.899	<.001	58	view →
LUAD	OS	Tertile	All	0.128	0.366	.001	37	view →
KIRP	DFS	Tertile	II,III,IV	0.143	0.892	<.001	34	view →
LUSC	DFS	Quartile	II,III,IV	0.330	0.769	.007	31	view →
HNSC	DFS	Median	IV	0.719	0.563	.002	29	view →
UVM	OS	Quartile	II,III,IV	0.448	0.920	.001	28	view →
ESCA	DFS	Tertile	III,IV	0.573	0.255	.011	20	view →
SKCM	OS	Quartile	III,IV	0.695	0.291	.002	19	view →
THCA	OS	Tertile	III,IV	0.917	1.000	.008	17	view →
UCS	OS	Tertile	II,III,IV	0.691	0.252	.016	16	view →
LGG	DFS	Quartile	All	0.390	0.636	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0046545–ACC (OS)

Open the ACC breakdown →