Development of primary female sexual characteristics

Across TCGA cell cohorts, RNA activity of the Development of primary female sexual characteristics pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLGN, EI24, and RNPEP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Development of primary female sexual characteristics activity versus CLGN in BLOOD_Myeloma (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLGN →	+3.017	+0.298	.008	.008	3	5
SOFT_TISSUE	EI24 →	-0.793	-0.249	.001	.003	3	4
LUNG_NSCLC_LUSC	RNPEP →	-1.049	-0.273	<.001	.008	3	4
LUNG_SCLC	ARPC2 →	-0.585	-0.229	.001	.001	2	4
LUNG_SCLC	TSEN54 →	+0.625	+0.342	.001	.003	3	3
SOFT_TISSUE	NOL6 →	-1.041	-0.198	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046545 vs CLGN — BLOOD_Myeloma

Explore this scatter interactively →