Sphingoid metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGPP1, STT3B_S498, and ALG5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingoid metabolic process activity versus SGPP1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SGPP1 →	+0.706	+0.412	<.001	<.001	3	4
UCEC	STT3B_S498 →	+0.861	+0.352	<.001	.001	3	4
UCEC	ALG5 →	+0.618	+0.347	<.001	.001	3	4
LSCC	SCAMP2 →	+0.276	+0.111	<.001	.009	2	4
UCEC	SURF4 →	+0.505	+0.307	<.001	<.001	3	3
UCEC	CD74_S8 →	+0.965	+0.266	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046519 vs SGPP1 — BRCA

Explore this scatter interactively →