Ceramide catabolic process

Across TCGA cell cohorts, RNA activity of the Ceramide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXB, LAMP1, and LRPAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide catabolic process activity versus HEXB in LUNG_SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HEXB →	+1.001	+1.145	.002	<.001	3	7
BONE	LAMP1 →	+2.043	+1.925	<.001	.002	3	6
SKIN	LRPAP1 →	+1.319	+0.456	.001	.002	3	6
SKIN	CTSA →	+1.273	+0.416	<.001	<.001	2	7
LUNG_NSCLC_LUAD	SPINT1 →	+3.553	+1.512	<.001	<.001	3	5
SOFT_TISSUE	ZC3H8 →	-1.106	-1.768	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046514 vs HEXB — LUNG_SCLC

Explore this scatter interactively →