Protoporphyrinogen IX metabolic process

Across TCGA patient cohorts, RNA activity of the Protoporphyrinogen IX metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR2, TPP1, and CC2D2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protoporphyrinogen IX metabolic process activity versus C5AR2 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C5AR2 →	+1.117	+0.099	<.001	.001	3	5
GBM	TPP1 →	+0.392	+0.087	.001	.001	3	4
BRCA	CC2D2B →	+0.228	+0.157	<.001	<.001	3	4
PDAC	GABPB1-AS1 →	+0.351	+0.109	.003	<.001	3	4
LUAD	FAM157C →	+0.262	+0.092	.002	.003	3	4
BRCA	MAN1A1 →	+0.830	+0.129	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046501 vs C5AR2 — BRCA

Explore this scatter interactively →