Glycerophospholipid catabolic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LOXL2, MLYCD, and FKBP9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid catabolic process activity versus LOXL2 in PDAC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LOXL2 →	-0.753	-0.046	<.001	<.001	3	5
PDAC	MLYCD →	+0.201	+0.041	<.001	<.001	3	5
CCRCC	FKBP9 →	-0.189	-0.028	.006	.003	3	5
GBM	ARRB1 →	+0.408	+0.041	<.001	<.001	3	5
GBM	TSPAN8 →	+1.345	+0.048	<.001	<.001	3	4
UCEC	OXSR1 →	-0.244	-0.055	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046475 vs LOXL2 — PDAC

Explore this scatter interactively →