Glycerophospholipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB1, TSPAN12, and RNF152, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB1 grouped by Glycerophospholipid catabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DDB1 →	+0.446	+0.809	.002	.005	3	3
LUNG_SCLC	TSPAN12 →	-2.271	-1.004	<.001	.001	3	3
LUNG_SCLC	RNF152 →	-1.336	-0.857	<.001	.007	3	3
BLOOD_Lymphoma	ZNF319 →	-0.567	-1.940	<.001	<.001	3	3
BLOOD_Lymphoma	R3HDM4 →	-0.818	-1.942	.004	<.001	3	3
LARGE_INTESTINE	BTN2A2 →	+1.039	+0.890	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB1 by Glycerophospholipid catabolic process activity — CNS

Explore this box plot interactively →