Glycerophospholipid catabolic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELFA, IL1RN, and HNRNPA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid catabolic process activity versus NELFA in OVARY (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NELFA →	+0.859	+0.226	.003	.009	3	6
BLOOD_Leukemia	IL1RN →	-2.438	-0.218	<.001	.001	3	6
PANCREAS	HNRNPA1 →	+0.945	+0.280	.007	.008	2	7
PANCREAS	CHEK1 →	+0.963	+0.240	.002	.007	2	6
SKIN	DIXDC1 →	+1.047	+0.218	.003	.008	3	5
SKIN	RBM12 →	+0.452	+0.191	.005	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046475 vs NELFA — OVARY

Explore this scatter interactively →