Phosphatidic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidic acid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRK, NR1H4, and CSK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRK grouped by Phosphatidic acid metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRK →	+0.284	+1.115	<.001	.002	3	5
LARGE_INTESTINE	NR1H4 →	-0.172	-1.109	.001	.002	3	5
LUNG_NSCLC_LUAD	CSK →	-0.174	-0.771	.001	.004	3	5
PANCREAS	CBX2 →	-0.136	-1.438	.006	<.001	3	5
STOMACH	MPG →	-0.332	-1.646	<.001	<.001	3	4
STOMACH	CORO1C →	-0.240	-1.446	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRK by Phosphatidic acid metabolic process activity — SKIN

Explore this box plot interactively →