Phosphatidic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1LG2, KRT80, and GNAI2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDCD1LG2 grouped by Phosphatidic acid metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDCD1LG2 →	-0.836	-0.846	.005	.003	3	7
STOMACH	KRT80 →	-3.233	-1.369	.006	<.001	3	7
LUNG_NSCLC_LUSC	GNAI2 →	-1.525	-1.292	.003	.004	3	6
LIVER	CCN1 →	-2.703	-1.364	.003	.005	2	7
LIVER	HERC4 →	-1.357	-1.364	.001	.005	2	7
LIVER	ITGA3 →	-4.463	-1.359	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDCD1LG2 by Phosphatidic acid metabolic process activity — OVARY

Explore this box plot interactively →