Phosphatidylglycerol metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC27, ZNF493, and ZNF397, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol metabolic process activity versus DNAJC27 in UVM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DNAJC27 →	+0.780	+0.024	<.001	<.001	3	22
ESCA	ZNF493 →	+0.764	+0.042	<.001	<.001	3	22
UVM	ZNF397 →	+0.955	+0.028	<.001	<.001	3	22
TGCT	ETFBKMT →	+0.738	+0.029	<.001	<.001	3	21
ACC	ABCA5 →	+0.965	+0.025	<.001	.002	3	21
KIRP	NFAT5 →	+1.373	+0.023	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046471 vs DNAJC27 — UVM

Explore this scatter interactively →