Phosphatidylglycerol metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMB, YBX2P1, and AOC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol metabolic process activity versus EMB in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EMB →	+0.664	+0.224	.003	<.001	3	4
UCEC	YBX2P1 →	+0.715	+0.172	.004	.007	3	3
UCEC	AOC1 →	-1.586	-0.219	<.001	<.001	3	3
HNSC	ZNF69 →	-0.575	-0.174	.002	.004	3	3
GBM	FBXO5 →	-0.670	-0.256	<.001	<.001	3	3
BRCA	ECT2 →	-0.933	-0.230	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046471 vs EMB — GBM

Explore this scatter interactively →