Phosphatidylglycerol metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9B2, TP53I11, and JTB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC9B2 grouped by Phosphatidylglycerol metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC9B2 →	+1.264	+1.313	.002	.004	3	4
LIVER	TP53I11 →	-3.385	-1.376	<.001	.006	3	4
OVARY	JTB →	-0.842	-1.181	<.001	<.001	3	4
URINARY_TRACT	ZNF561 →	+1.403	+1.798	<.001	<.001	3	4
BLOOD_Myeloma	TNFAIP8L1 →	+0.904	+1.143	.001	.003	3	3
OESOPHAGUS	MTMR9 →	+0.958	+1.640	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC9B2 by Phosphatidylglycerol metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →