Phosphatidylglycerol metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TC2N, TBC1D30, and PCSK6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol metabolic process activity versus TC2N in URINARY_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TC2N →	+3.294	+0.359	.001	<.001	3	6
URINARY_TRACT	TBC1D30 →	+1.900	+0.277	.004	.002	3	4
URINARY_TRACT	PCSK6 →	+4.425	+0.398	<.001	<.001	3	4
URINARY_TRACT	EPHA1 →	+3.668	+0.338	.002	.002	3	4
URINARY_TRACT	LAD1 →	+6.137	+0.386	<.001	<.001	3	4
URINARY_TRACT	GRHL2 →	+4.218	+0.294	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046471 vs TC2N — URINARY_TRACT

Explore this scatter interactively →