Phosphatidylcholine metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHEK2, ALDH1A1, and GPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine metabolic process activity versus CHEK2 in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHEK2 →	-0.473	-0.056	<.001	<.001	3	6
BRCA	ALDH1A1 →	+0.555	+0.020	<.001	<.001	3	6
GBM	GPD1 →	+1.164	+0.052	<.001	<.001	3	6
LSCC	SEPTIN4_S107 →	+0.761	+0.036	<.001	<.001	3	5
LUAD	SHE_S69 →	+0.724	+0.038	<.001	<.001	3	5
CCRCC	SVIL_S547 →	+0.879	+0.028	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046470 vs CHEK2 — GBM

Explore this scatter interactively →