Platelet activating factor metabolic process

Across TCGA patient cohorts, RNA activity of the Platelet activating factor metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS, NFATC2, and NASP_S421, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet activating factor metabolic process activity versus THEMIS in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	THEMIS →	+0.626	+0.091	<.001	<.001	3	7
GBM	NFATC2 →	+0.363	+0.078	<.001	<.001	3	6
LUAD	NASP_S421 →	-0.817	-0.058	<.001	<.001	3	6
GBM	ARRB1 →	+0.358	+0.067	.001	.002	3	5
LUAD	SELENBP1 →	+0.586	+0.058	<.001	<.001	3	5
LUAD	SOD3 →	+0.415	+0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046469 vs THEMIS — GBM

Explore this scatter interactively →