Monoacylglycerol metabolic process

Across TCGA patient cohorts, RNA activity of the Monoacylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, RASGRP4, and KRT33B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoacylglycerol metabolic process activity versus PLA2G4A in UCEC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+1.686	+0.233	<.001	<.001	3	7
GBM	RASGRP4 →	+0.322	+0.160	<.001	<.001	3	4
UCEC	KRT33B →	+0.793	+0.194	.004	.001	3	3
OV	HDAC1P2 →	+0.306	+0.212	.005	.001	3	3
UCEC	ABHD6 →	+0.888	+0.301	<.001	<.001	3	3
LUAD	ADORA2BP1 →	+0.229	+0.334	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046462 vs PLA2G4A — UCEC

Explore this scatter interactively →