Neutral lipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Neutral lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAM1, HLA-DQB1-AS1, and SCHIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid biosynthetic process activity versus DRAM1 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DRAM1 →	+0.409	+0.205	.001	<.001	3	4
GBM	HLA-DQB1-AS1 →	+0.761	+0.148	.002	.007	3	4
CCRCC	SCHIP1 →	-0.506	-0.221	.005	.005	3	4
GBM	GMFG →	+0.673	+0.193	<.001	.002	3	3
LSCC	BATF3 →	+0.356	+0.192	.001	.002	3	3
LSCC	KATNBL1 →	-0.417	-0.198	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046460 vs DRAM1 — GBM

Explore this scatter interactively →