Neutral lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF37, NBPF19, and USP13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF37 grouped by Neutral lipid biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ARHGEF37 →	+1.396	+1.161	.001	.006	3	4
LARGE_INTESTINE	NBPF19 →	-0.695	-1.080	.005	.001	3	4
LUNG_NSCLC_LUSC	USP13 →	-0.972	-0.911	<.001	.002	3	4
URINARY_TRACT	H2AC14 →	+1.252	+1.495	.005	.009	3	4
LUNG_SCLC	HSPBP1 →	+0.842	+1.007	.008	.005	3	3
LUNG_SCLC	CAPN1 →	+0.913	+0.811	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF37 by Neutral lipid biosynthetic process activity — PANCREAS

Explore this box plot interactively →