Neutral lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCK2, LHFPL6, and CDCA7L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid biosynthetic process activity versus PCK2 in STOMACH (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PCK2 →	+2.081	+1.453	<.001	<.001	3	7
LUNG_NSCLC_LUAD	LHFPL6 →	-1.194	-0.747	.005	<.001	3	5
URINARY_TRACT	CDCA7L →	-2.047	-1.361	.005	<.001	3	5
URINARY_TRACT	MRPS24 →	-1.050	-1.458	.005	.001	3	5
BREAST	TMEM231 →	-1.070	-0.926	.001	.002	3	4
PANCREAS	ARHGEF38 →	+1.308	+1.000	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046460 vs PCK2 — STOMACH

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