Prostanoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Prostanoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYBG3, SYNPO2_T755, and TFPI, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid biosynthetic process activity versus CRYBG3 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRYBG3 →	+0.310	+0.034	<.001	<.001	3	8
GBM	SYNPO2_T755 →	+0.685	+0.089	<.001	<.001	3	7
LSCC	TFPI →	+0.598	+0.063	<.001	<.001	3	7
UCEC	TLN1 →	+0.268	+0.050	.005	<.001	3	7
GBM	U2SURP →	-0.318	-0.096	<.001	<.001	3	7
BRCA	CNN1 →	+0.856	+0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046457 vs CRYBG3 — BRCA

Explore this scatter interactively →