Prostanoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Prostanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, ATP6V1C1, and GPR143, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid biosynthetic process activity versus CBR1 in BREAST (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CBR1 →	+1.826	+0.162	.008	.004	3	5
OESOPHAGUS	ATP6V1C1 →	+0.682	+0.265	<.001	.001	3	4
LUNG_SCLC	GPR143 →	-1.101	-0.217	.005	.002	3	4
LUNG_SCLC	HDAC7 →	-1.419	-0.247	.001	.005	3	4
LUNG_NSCLC_LUAD	ARHGDIB →	-2.928	-0.290	.004	.001	3	4
LUNG_NSCLC_LUAD	SDC4 →	-0.956	-0.220	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046457 vs CBR1 — BREAST

Explore this scatter interactively →