Icosanoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTKN2, STAT5A, and PHLDB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid biosynthetic process activity versus RTKN2 in STOMACH (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RTKN2 →	-2.231	-0.302	.003	.007	3	5
BLOOD_Leukemia	STAT5A →	-1.962	-0.150	<.001	.005	3	5
OVARY	PHLDB2 →	-1.583	-0.252	.007	<.001	3	5
BLOOD_Leukemia	GOLPH3L →	-0.499	-0.183	.003	<.001	3	4
BLOOD_Leukemia	PELI3 →	+0.812	+0.177	.002	.002	3	4
LIVER	PIK3CD →	-1.604	-0.374	.004	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046456 vs RTKN2 — STOMACH

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