Organophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Organophosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SELENBP1, SPATS2, and SMG8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate catabolic process activity versus SELENBP1 in PDAC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SELENBP1 →	+0.238	+0.015	.003	.007	3	6
CCRCC	SPATS2 →	-0.307	-0.030	<.001	<.001	3	6
GBM	SMG8 →	-0.138	-0.033	<.001	<.001	3	5
UCEC	SPR →	+0.397	+0.036	.002	.002	3	5
BRCA	UTP4 →	-0.315	-0.015	.006	.003	3	5
BRCA	AAAS →	-0.244	-0.014	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046434 vs SELENBP1 — PDAC

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