Organophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Organophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEGF9, IRF2BP2, and SLC44A5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEGF9 grouped by Organophosphate catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MEGF9 →	-1.687	-0.157	<.001	.001	3	5
BREAST	IRF2BP2 →	-0.691	-0.187	.002	<.001	3	5
URINARY_TRACT	SLC44A5 →	-2.054	-0.337	.001	<.001	3	5
LARGE_INTESTINE	SREBF1 →	-0.991	-0.199	.005	.002	3	5
LUNG_SCLC	COQ8A →	-1.595	-0.177	<.001	<.001	3	5
STOMACH	IFIT1 →	+2.146	+0.146	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEGF9 by Organophosphate catabolic process activity — LUNG_SCLC

Explore this box plot interactively →