Organophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Organophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPK2, STX2, and CDH3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organophosphate catabolic process activity versus UPK2 in LUNG_NSCLC_LUAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UPK2 →	-1.706	-0.227	.001	<.001	3	7
STOMACH	STX2 →	+1.485	+0.389	.001	.001	2	7
URINARY_TRACT	CDH3 →	-5.986	-0.619	<.001	.003	3	6
OVARY	DSC2 →	-2.531	-0.401	<.001	<.001	3	6
OESOPHAGUS	PIP4K2A →	+0.963	+0.253	.001	.004	2	7
LUNG_NSCLC_LUAD	ZEB1 →	+2.186	+0.233	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046434 vs UPK2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →