Negative regulation of receptor signaling pathway via JAK-STAT

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor signaling pathway via JAK-STAT pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C6, SERPING1, and F13B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via JAK-STAT activity versus C6 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C6 →	+0.586	+0.061	<.001	<.001	3	8
GBM	SERPING1 →	+0.507	+0.058	<.001	<.001	3	8
BRCA	F13B →	+0.476	+0.044	<.001	<.001	3	8
GBM	PROS1 →	+0.594	+0.060	<.001	<.001	3	8
OV	C1S →	+0.640	+0.048	<.001	.001	3	8
GBM	C1R →	+0.526	+0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046426 vs C6 — GBM

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