Negative regulation of receptor signaling pathway via JAK-STAT

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAX1BP3, FN1, and NDUFAF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAX1BP3 grouped by Negative regulation of receptor signaling pathway via JAK-STAT-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TAX1BP3 →	-0.655	-1.167	.008	.002	3	5
LUNG_NSCLC_LUSC	FN1 →	-4.500	-1.103	<.001	.005	3	4
BREAST	NDUFAF6 →	+1.101	+0.965	<.001	.001	3	4
BLOOD_Lymphoma	LUZP1 →	-1.085	-1.861	.004	<.001	3	4
BREAST	CCDC80 →	-1.892	-0.813	.005	<.001	3	4
LUNG_NSCLC_LUSC	EMC3 →	-0.744	-1.158	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAX1BP3 by Negative regulation of receptor signaling pathway via JAK-STAT activity — OVARY

Explore this box plot interactively →